On the design of a sustainable ocean drifter for developing countries

More than fifty low and medium income countries rely on the sea for their economies. Despite its importance, there is a lack of oceanographic scientific data from these countries due to the high cost of equipment and to the running costs of measurement campaigns. In this paper we present a low-cost drifter based on a LoRa communication platform and tested in a coastal area (Gulf of Trieste). The system, built using low-cost off-the-shelf components, has at least the same performances of drifters that costs about three times as much and its operation does not require any recurring costs. The use of a LoRa allows several drifters to operate simultaneously in the same area, providing a rich and homogeneous database for the statistical post processing. The high transmission rate allows an almost instantaneous position determination, facilitating the drifter recovery for successive reuse, which essential in developing countries

A Low-Cost and Low-Power Messaging System Based on the LoRa Wireless Technology

[EN] In this paper we describe a low-cost and low-power consumption messaging system based on LoRa technology. More that one billion people worldwide cannot access even the most basic connectivity services. For them even simple messaging services would be of great help, for example to farmers wishing to know the price of goods they want to sell or buy before deciding whether a possibly long, expensive and exhausting trip is undertaken. LoRa networks allow for very long wireless links that can connect villages and towns. This system falls in the category of community networks, where users build their own network where no commercial infrastructure is available. In addition to the simple messaging application, LoRa can be used to distribute sensor information to communities or to provide disaster alerts or meteorological data.Moreno Cardenas, A.; Nakamura Pinto, MK.; Pietrosemoli, E.; Zennaro, M.; Rainone, M.; Manzoni, P. (2020). A Low-Cost and Low-Power Messaging System Based on the LoRa Wireless Technology. Mobile Networks and Applications (Online). 25(3):961-968. https://doi.org/10.1007/s11036-019-01235-5S96196825

Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity

Live-cell microscopy has highlighted that transcription factors bind transiently to chromatin but it is not clear if the duration of these binding interactions can be modulated in response to an activation stimulus, and if such modulation can be controlled by post-translational modifications of the transcription factor. We address this question for the tumor suppressor p53 by combining live-cell single-molecule microscopy and single cell in situ measurements of transcription and we show that p53-binding kinetics are modulated following genotoxic stress. The modulation of p53 residence times on chromatin requires C-terminal acetylation - a classical mark for transcriptionally active p53 - and correlates with the induction of transcription of target genes such as CDKN1a. We propose a model in which the modification state of the transcription factor determines the coupling between transcription factor abundance and transcriptional activity by tuning the transcription factor residence time on target sites

Pathology reporting in neuroendocrine neoplasms of the digestive system: everything you always wanted to know but were too afraid to ask

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals

Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management

In the issue of March 2021, Lenschow et al. reported the case of a 46-year-old woman with recurrent, programmed death-ligand-1 (PD-L1) negative, tumor mutational burden (TMB)-high parathyroid carcinoma (PC), who showed stable disease as her best response on imaging, and a three-fold drop in PTH after treatment with intravenous pembrolizumab. Given the remarkable results obtained by Lenschow et al. with the anti-PD-1 agent pembrolizumab in the above-mentioned case, we performed an extensive search for possible further relevant data sources, including a) full published articles in international online databases (PubMed, Web of Science, Scopus, and Embase); b) preliminary reports in selected international meeting abstract repositories (American Society of Clinical Oncology, ASCO; European Neuroendocrine Tumor Society, ENET; European Society for Medical Oncology, ESMO); c) registered clinical trials in the U.S. National Institutes of Health registry of clinical trials (http://clinicaltrials.gov) and in any primary register of the WHO International Clinical Trials Registry Platform (ICTRP)

Endogenous social interactions with unobserved networks

We present a model of endogenous network formation to recover unobserved social networks using only observable outcomes. We propose a novel equilibrium concept that allows for a sharp characterization of equilibrium behaviour and that yields a unique prediction under testable conditions. While the equilibrium is characterized by a large number of non-linear equations, we show that it can be efficiently employed to recover the networks by an appropriately designed approximate Bayesian computation method. We apply the model to recover the network of social links between lawmakers in the U.S. Congress using data from the 109th to 113th legislatures. We show that social connections are important for legislators' productivities, and we identify some of the key determinants of network centralities in the U.S. Congress

Injury patterns and causes of death in 953 patients with penetrating abdominal war wounds in a civilian independent non-governmental organization hospital in Lashkargah, Afghanistan

Background Management of penetrating abdominal war injuries centers upon triage, echeloned care, and damage control. A civilian hospital based in a war zone can rarely rely upon these principles because it normally has limited resources and lacks rapid medical evacuation. We designed this study to describe organ injury patterns and factors related to mortality in patients with penetrating abdominal war injuries in a civilian hospital in an active war zone in Afghanistan, examine how these findings differ from those in a typical military setting, and evaluate how they might improve patients’ care. Methods We reviewed the records of all patients admitted at the Lashkargah “Emergency” hospital with penetrating abdominal injuries treated from January 2006 to December 2016. Demographic and clinical data were recorded; univariate and multivariate analyses were used to identify variables significantly associated with death. Results We treated 953 patients for penetrating abdominal injury. The population was mainly civilian (12.1% women and 21% under 14). Mean age was 23 years, and patients with blast injuries were younger than in the other groups. The mechanism of injury was bullet injury in 589 patients, shell injury in 246, stab wound in 97, and mine injury in 21. The most frequent abdominal lesion was small bowel injury (46.3%). Small and large bowel injuries were the most frequent in the blast groups, stomach injury in stab wounds. Overall mortality was 12.8%. Variables significantly associated with death were age > 34 years, mine and bullet injury, length of stay, time since injury > 5 h, injury severity score > 17, and associated injuries. Conclusions Epidemiology and patterns of injury in a civilian hospital differ from those reported in a typical military setting. Our population is mainly civilian with a significant number of women and patients under 14 years. BI are more frequent than blast injuries, and gastrointestinal injuries are more common than injuries to solid organs. In this austere setting, surgeons need to acquire a wide range of skills from multiple surgical specialties. These findings might guide trauma and general surgeons treating penetrating abdominal war wounds to achieve better care and outcome

Reflexivity in Higher Education - Research and Models of Intervention for Underachieving Students

There is a rapidly increasing demand to implement formative methods in university contexts to promote reflexive competences. Underachieving university students often evince reflexive impairments when dealing with specific university–related events and relationships, or specific developmental milestones (transition to university, fundamental exams, etc.). Fostering reflexivity can be conducive for them to improving their active participation and inclusion to university contexts. The book aims at contributing to the debate on reflexive process as well as on the role that narrative devices can play to foster it. It also aims at discussing the difficult conditions of many university students, the need of promoting key competences and to test novel formative methods in order to improve students’ academic performance. Many contributors by different European scholars will be presented. Much of them are aimed at discussing the European Project INSTALL (Innovative Solutions to Acquire Learning to Learn) founded in 2011 within the Erasmus Multilateral Project. INSTALL adopts an innovative narrative and multimodal methodology, the Narrative Mediation Path (NMP), i.e. a narrative formative method devised and tested with underachieving university students lagging behind with their studies